(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

Base Information

Chemical Name:(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate
CAS No.:1394124-11-8
Molecular Formula:C₂₁H₁₆Cl₂N₂O₄
Molecular Weight:431.275
Hs Code.:

Synonyms:(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

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Chemical Property of (E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

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Technology Process of (E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

There total 8 articles about (E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1394124-10-7
methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3,3-dimethoxypropanoate

: 1394124-11-8
(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

Guidance literature:: With methanesulfonic acid; acetic anhydride; at 90 ℃; for 2h;
DOI:10.1002/cjoc.201200101

Reference yield:

: 40800-90-6
3-(α-methoxy)methylene benzofuran-2-(3H)-ketone

: 1394124-11-8
(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 1 h / -10 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3: methanesulfonic acid; acetic anhydride / 2 h / 90 °C

With methanesulfonic acid; acetic anhydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201200101

Reference yield:

: 83217-77-0
2-p-chlorophenyl-4,6-dihydroxypyrimidine

: 1394124-11-8
(E)-methyl 2-(2-(6-chloro-2-(4-chlorophenyl)pyrimidin-4-yloxy)phenyl)-3-(methoxy)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

3: methanesulfonic acid; acetic anhydride / 2 h / 90 °C

With methanesulfonic acid; acetic anhydride; potassium carbonate; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/cjoc.201200101