2-Pyridinecarboxaldehyde,1,6-dihydro-6-oxo-(9CI)

Base Information

• Chemical Name: 2-Pyridinecarboxaldehyde,1,6-dihydro-6-oxo-(9CI)
• CAS No.: 358751-77-6
• Molecular Formula: C6H5 N O2
• Molecular Weight: 123.11
• Hs Code.: 2933399090
• Mol file: 358751-77-6.mol

Synonyms:6-Formyl-2-pyridinone;6-Hydroxypyridine-2-carboxaldehyde; 6-Oxo-1,6-dihydropyridine-2-carboxaldehyde

Chemical Property of 2-Pyridinecarboxaldehyde,1,6-dihydro-6-oxo-(9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.629
• Boiling Point: 334.629°C at 760 mmHg
• PKA: 9.33±0.10(Predicted)
• Flash Point: 156.178°C
• PSA: 50.19000
• Density: 1.327g/cm³
• LogP: 0.59970
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Hydroxypyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridinecarboxaldehyde,1,6-dihydro-6-oxo-(9CI)

There total 4 articles about 2-Pyridinecarboxaldehyde,1,6-dihydro-6-oxo-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-(tert-butoxy)picolinaldehyde (195044-13-4) → 6-oxo-1,6-dihydropyridine-2-carbaldehyde (358751-77-6)

Guidance literature:

With formic acid; In water; at 20 ℃; for 10h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b03395

Reference yield: 22.0%

6-hydroxymethylpyridin-2-ol (352514-21-7) → 6-hydroxypicolinaldehyde (358751-77-6)

Guidance literature:

With manganese(IV) oxide; In pyridine; at 20 ℃; for 72h;

Reference yield:

6-bromo-2-(1,1-dimethylethoxy)pyridine (949160-14-9) → 6-oxo-1,6-dihydropyridine-2-carbaldehyde (358751-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C / Inert atmosphere; Schlenk technique

1.2: 1 h / -78 °C / Inert atmosphere; Schlenk technique

2.1: formic acid / water / 10 h / 20 °C / Inert atmosphere; Schlenk technique

With n-butyllithium; formic acid; In tetrahydrofuran; hexane; water;

DOI:10.1021/acs.orglett.7b03395

upstream raw materials:

6-hydroxymethylpyridin-2-ol

6-bromo-2-(1,1-dimethylethoxy)pyridine

6-(tert-butoxy)picolinaldehyde

2,6-Dibromopyridine

Refernces

• 1、 -. "Gonadotropin releasing hormone receptor antagonists". Page/Page column 27. . Retrieved 2010/02/15.