(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

Base Information

Chemical Name:(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran
CAS No.:106456-11-5
Molecular Formula:C₂₈H₄₂O₅Si
Molecular Weight:486.724
Hs Code.:

(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

Synonyms:(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

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Chemical Property of (2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

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Technology Process of (2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

There total 6 articles about (2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98903-51-6
(1aα,3α,3aα,7aβ,7bα)-3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1a,2,3,3a,7a,7b-hexahydro-6-methyl-5H-oxireno<1>benzopyran-5-one

: 106456-11-5
(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / diisobutylaluminum hydride / toluene; hexane / 2.5 h / -78 - -40 °C

2: 85 percent / BF₃*OEt₂ / 6 h / -20 °C

3: boron trifluoride etherate / hexane; tetrahydrofuran / 3 h / -78 °C

4: 1.) NaH, tetra-n-butylammonium iodide / 1.) THF, 2.) RT, 21 h

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/jo00380a025

Reference yield:

: 106455-98-5
3-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-1a,3,3a,5,7a,7b-hexahydro-6-methyl-2H-oxireno<1>benzopyran-5-ol

: 106456-11-5
(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / BF₃*OEt₂ / 6 h / -20 °C

2: boron trifluoride etherate / hexane; tetrahydrofuran / 3 h / -78 °C

3: 1.) NaH, tetra-n-butylammonium iodide / 1.) THF, 2.) RT, 21 h

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/jo00380a025

Reference yield:

: 98903-53-8,106499-50-7
(1aα,3α,3aα,5α,7aβ,7bα)-(1,1-dimethylethyl)-<<1a,3,3a,5,7a,7b-hexahydro-5-methoxy-6-methyl-2H-oxireno<1>benzopyran-3-yl>oxy>dimethylsilane

: 106456-11-5
(2α,4aβ,5α,6β,8α,8aα)-8-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-4a,5,6,7,8,8a-hexahydro-2-methoxy-5-(3-methoxy-1-propynyl)-3-methyl-6-(phenylmethoxy)-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride etherate / hexane; tetrahydrofuran / 3 h / -78 °C

2: 1.) NaH, tetra-n-butylammonium iodide / 1.) THF, 2.) RT, 21 h

With boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane;
DOI:10.1021/jo00380a025