2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

Base Information

Chemical Name:2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide
CAS No.:1289562-84-0
Molecular Formula:C₂₁H₂₀N₂O₃
Molecular Weight:348.401
Hs Code.:

Synonyms:2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

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Chemical Property of 2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

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Technology Process of 2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

There total 16 articles about 2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1289562-83-9
2-((tert-butyldimethylsilyloxy)(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

: 1289562-84-0
2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm101597x

Reference yield: 98.0%

: 1289562-84-0
2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

Guidance literature:

Reference yield:

: 65844-44-2
methyl 6-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate

: 1289562-84-0
2-(hydroxy(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methyl)oxazole-5-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

5.1: borane-THF / tetrahydrofuran / 1 h / 20 °C

5.2: 0.67 h / -78 °C

5.3: 2 h / -78 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

7.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

7.2: 0.08 h

8.1: n-butyllithium / tetrahydrofuran / 2 h / -78 °C

8.2: 0.08 h

9.1: ammonia / methanol / 2 h / 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; borane-THF; tetrabutyl ammonium fluoride; ammonia; sodium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 2.1: Suzuki coupling;
DOI:10.1021/jm101597x