1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

Base Information

Chemical Name:1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol
CAS No.:1331836-45-3
Molecular Formula:C₁₈H₂₁NO₄S
Molecular Weight:347.435
Hs Code.:

Synonyms:1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

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Chemical Property of 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

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Technology Process of 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

There total 2 articles about 1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1331836-65-7
C₁₅H₁₅NO₄S

: 1730-25-2
allylmagnesium bromide

: 1331836-45-3
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

Guidance literature:: C₁₅H₁₅NO₄S; allylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at 0 - 20 ℃; Saturated solution;
DOI:10.1021/ol201510u

Reference yield:

: 1229516-61-3
3-bromo-1-(phenylsulfonyl)-1H-pyrrole-2-carbaldehyde

: 1331836-45-3
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 4.5 h / 65 °C

2.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Saturated solution

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; diethyl ether; water; 1.1: Suzuki-Miyaura coupling;
DOI:10.1021/ol201510u

Reference yield:

: 1331836-45-3
1-(3-(3-methoxyprop-1-en-2-yl)-1-(phenylsulfonyl)-1H-pyrrol-2-yl)but-3-en-1-ol

: C₁₆H₁₇NO₄S

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol201510u