ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Base Information

Chemical Name:ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate
CAS No.:1415574-04-7
Molecular Formula:C₂₆H₃₀F₃N₅O₃
Molecular Weight:517.551
Hs Code.:

Synonyms:ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

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Chemical Property of ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

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Technology Process of ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

There total 10 articles about ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6-trifluoromethylpyridine-2,3-diamine dihydrochloride

: 1415573-51-1
trans-ethyl 4-((1-(5-formylpyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

: 1415574-04-7
ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: 6-trifluoromethylpyridine-2,3-diamine dihydrochloride; trans-ethyl 4-((1-(5-formylpyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate; With Oxone; In water; N,N-dimethyl-formamide; at 50 ℃; for 16h;

With potassium carbonate; In water; N,N-dimethyl-formamide; for 0.166667h;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415574-04-7
ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C

2.1: ChiralPak AD-H / Resolution of racemate

3.1: hydrogen; acetic acid / platinum(IV) oxide

4.1: sodium hydrogencarbonate / dimethyl sulfoxide / 2 h / 110 °C / Inert atmosphere

5.1: Oxone / N,N-dimethyl-formamide; water / 16 h / 50 °C

5.2: 0.17 h

With Oxone; di-isopropyl azodicarboxylate; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1415574-04-7
ethyl trans-4-[(1-{5-[5-(trifluoromethyl)-3H-imidazo[4,5-b]pyridin-2-yl]pyridin-2-yl}piperidin-4-yl)oxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; NADP; ketoreductase MIF₂₀ / water / 20 h / 30 °C / pH 7

2.1: chloro-trimethyl-silane; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: -65 - 0 °C

3.1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 6 h

4.1: sodium hydrogencarbonate / dimethyl sulfoxide / 2 h / 110 °C / Inert atmosphere

5.1: Oxone / N,N-dimethyl-formamide; water / 16 h / 50 °C

5.2: 0.17 h

With hydrogenchloride; Oxone; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; chloro-trimethyl-silane; ketoreductase MIF₂₀; hydrogen; NADP; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;