2-Phenylpiperidine hydrochloride

Base Information

Chemical Name:2-Phenylpiperidine hydrochloride
CAS No.:3466-81-7
Molecular Formula:C₁₁H₁₅N*ClH
Molecular Weight:197.708
Hs Code.:
European Community (EC) Number:815-843-7

Synonyms:2-phenylpiperidine hydrochloride;3466-81-7;2-phenylpiperidine;hydrochloride;2-Phenylpiperidine HCl;37656-36-3;2-phenylpiperidinehydrochloride;SCHEMBL1764935;YNQTWZUWWFUKSN-UHFFFAOYSA-N;MFCD02179093;2-phenyl-piperidine hydrochloride salt;AKOS015958971;AT22864;SB42594;SB46232;PD180692;CS-0233853;EN300-136570

Suppliers and Price of 2-Phenylpiperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 13 raw suppliers

Chemical Property of 2-Phenylpiperidine hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:197.0971272
Heavy Atom Count:13
Complexity:127

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCNC(C1)C2=CC=CC=C2.Cl

Technology Process of 2-Phenylpiperidine hydrochloride

There total 3 articles about 2-Phenylpiperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1261144-92-6
2-phenyl-1-(pyridin-2-yl)piperidine

: 3466-81-7,155106-18-6
2-phenylpiperidine hydrochloride

Guidance literature:: 2-phenyl-1-(pyridin-2-yl)piperidine; With methyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 0.1h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; acetonitrile; at 0 ℃; for 0.25h; Inert atmosphere;

With hydrogenchloride; In methanol; water; acetonitrile; for 0.0166667h; Inert atmosphere;
DOI:10.1021/jo401521y

Reference yield:

: 75844-69-8
t-butyl piperidinecarboxylate

: 3466-81-7,155106-18-6
2-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 3 h / -78 °C

1.2: -78 - 20 °C

1.3: 15 h

2.1: hydrogenchloride / dichloromethane / 5 h / 20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1111/bph.14388

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 3466-81-7,155106-18-6
2-phenylpiperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: sec.-butyllithium; N,N,N,N,-tetramethylethylenediamine / tetrahydrofuran / 3 h / -78 °C

1.2: -78 - 20 °C

1.3: 15 h

2.1: hydrogenchloride / dichloromethane / 5 h / 20 °C

With hydrogenchloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; dichloromethane;
DOI:10.1111/bph.14388