5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

Base Information

Chemical Name:5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine
CAS No.:1083428-83-4
Molecular Formula:C₂₁H₁₈F₃N₅O₂
Molecular Weight:429.401
Hs Code.:

Synonyms:5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

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Chemical Property of 5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

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Technology Process of 5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

There total 6 articles about 5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79456-34-1
5-bromo-3-(trifluoromethyl)pyridin-2-amine

: 1083429-88-2
6-(3,4-dimethoxy-phenyl)-2-methyl-3-trimethylstannanyl-imidazo[1,2-b]pyridazine

: 1083428-83-4
5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1023717-14-7
6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazine

: 1083428-83-4
5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 4 h / 125 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ISOPROPYLAMIDE; N,N-dimethyl-formamide; toluene;

Reference yield:

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1083428-83-4
5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-3-trifluoromethyl-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 20 h / 105 °C

2: triethylamine / ethanol / 0.5 h / 170 °C / Microwave irradiation

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 4 h / 125 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ISOPROPYLAMIDE / 1 h / 150 °C / Microwave irradiation

With N-Bromosuccinimide; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; ISOPROPYLAMIDE; water; N,N-dimethyl-formamide; toluene;