1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Base Information

Chemical Name:1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone
CAS No.:1148045-86-6
Molecular Formula:C₂₄H₂₃F₃IN₅O₂S
Molecular Weight:629.445
Hs Code.:

Synonyms:1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Chemical Property of 1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

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Technology Process of 1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

There total 8 articles about 1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003319-95-6
1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide

: 1173697-80-7
2-chloro-1-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]ethanone

: 1148045-86-6
1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: 1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidine-4-carbothioic acid amide; 2-chloro-1-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]ethanone; With tetrabutylammomium bromide; In acetone; for 12h; Reflux;

With sodium hypochlorite; sodium hydrogencarbonate; In water; pH=8;

Reference yield:

: 1003320-13-5
1-(2-chloroacetyl)-N-(1,1-dimethylethyl)-4-piperidinecarboxamide

: 1148045-86-6
1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / N,N-dimethyl-formamide / 37 - 55 °C

2.1: potassium hydroxide / water; N,N-dimethyl-formamide / 8 h / 5 - 10 °C

3.1: hydrogen sulfide; 2,2'-iminobis[ethanol] / N,N-dimethyl-formamide / 50 °C

4.1: tetrabutylammomium bromide / acetone / 12 h / Reflux

4.2: pH 8

With hydrogen sulfide; tetrabutylammomium bromide; 2,2'-iminobis[ethanol]; potassium hydroxide; trichlorophosphate; In water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 696-41-3
m-iodobenzaldehyde

: 1148045-86-6
1-[4-[4-[4,5-dihydro-5-(3-iodophenyl)-3-isoxazolyl]-2-thiazolyl]-1-piperidinyl]-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

2.1: sodium hydrogencarbonate / acetonitrile / 12 h / 20 °C

3.1: tetrabutylammomium bromide / acetone / 12 h / Reflux

3.2: pH 8

With potassium tert-butylate; tetrabutylammomium bromide; sodium hydrogencarbonate; In tetrahydrofuran; acetone; acetonitrile;