2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

Base Information

Chemical Name:2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid
CAS No.:1311277-21-0
Molecular Formula:C₂₆H₂₅F₃N₂O₄S
Molecular Weight:518.557
Hs Code.:

Synonyms:2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

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Chemical Property of 2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

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Technology Process of 2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

There total 9 articles about 2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉F₃N₂O₄S

: 1311277-21-0
2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

Guidance literature:: C₂₈H₂₉F₃N₂O₄S; With lithium hydroxide monohydrate; In ethanol; water; for 2h; Reflux;

With hydrogenchloride; In ethanol; water; Cooling with ice;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 515138-24-6
6-acetamido-3-[2-[2-[(4-trifluoromethyl)phenyl]-4-isopropyl-5-thiazolyl]ethyl]-1,2-benzisoxazole

: 1311277-21-0
2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; water; acetic acid / 24 h / Reflux

1.2: Cooling with ice

2.1: sulfuric acid; water; sodium nitrite / 3.33 h / 0 - 130 °C

3.1: potassium carbonate / butanone / 45 h / Reflux

4.1: lithium hydroxide monohydrate / ethanol; water / 2 h / Reflux

4.2: Cooling with ice

With hydrogenchloride; lithium hydroxide monohydrate; sulfuric acid; water; potassium carbonate; acetic acid; sodium nitrite; In ethanol; water; butanone;
DOI:10.1016/j.bmc.2011.03.053

Reference yield:

: 515138-26-8
6-amino-3-[2-[2-[(4-trifluoromethyl)phenyl]-4-isopropyl-5-thiazolyl]ethyl]-1,2-benzisoxazole

: 1311277-21-0
2-[3-[2-[4-isopropyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]ethyl]-1,2-benzisoxazol-6-yloxy]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; water; sodium nitrite / 3.33 h / 0 - 130 °C

2.1: potassium carbonate / butanone / 45 h / Reflux

3.1: lithium hydroxide monohydrate / ethanol; water / 2 h / Reflux

3.2: Cooling with ice

With lithium hydroxide monohydrate; sulfuric acid; water; potassium carbonate; sodium nitrite; In ethanol; water; butanone;
DOI:10.1016/j.bmc.2011.03.053