6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine

Base Information

• Chemical Name: 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine
• CAS No.: 1092063-12-1
• Molecular Formula: C₁₄H₁₂ClN₃
• Molecular Weight: 257.722
• Mol file: 1092063-12-1.mol

Synonyms:6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine

Chemical Property of 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine

There total 5 articles about 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

6-chloro-3-methyl-1H-pyrazolo[4,3-c]pyridine (1092062-74-2) + 4-methylphenylboronic acid (5720-05-8) → 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine (1092063-12-1)

Guidance literature:

With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1021/acs.jmedchem.7b00210

Reference yield:

6-chloro-3-methyl-1H-pyrazolo[4,3-c]pyridine (1092062-74-2) → 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine (1092063-12-1)

Guidance literature:

With copper(l) iodide; dimethylaminoacetic acid; potassium carbonate; In dimethyl sulfoxide; at 100 ℃;

DOI:10.1016/j.bmcl.2008.08.095

Reference yield:

1-(4,6-dichloropyridin-3-yl)ethan-1-one (887573-44-6) → 6-chloro-3-methyl-1-p-tolyl-1H-pyrazolo[4,3-c]pyridine (1092063-12-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; hydrazine hydrate / isopropyl alcohol / 16 h / Reflux; Inert atmosphere

2: copper diacetate; pyridine / dichloromethane / 3.5 h / 20 °C

With pyridine; copper diacetate; hydrazine hydrate; triethylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1021/acs.jmedchem.7b00210

upstream raw materials:

6-chloro-3-methyl-1H-pyrazolo[4,3-c]pyridine

1-(4,6-dichloropyridin-3-yl)ethan-1-one

4-methylphenylboronic acid

4,6-dichloro-nicotinic acid

Downstream raw materials:

C₂₂H₂₂N₄