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Technology Process of (1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE

(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE

Base Information
  • Chemical Name:(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE
  • CAS No.:357400-13-6
  • Molecular Formula:C30H38 F N3 O2 . 2 Cl H
  • Molecular Weight:564.5619032
  • Hs Code.:
  • Mol file:357400-13-6.mol
(1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE

Synonyms:Cyclopropanecarboxylicacid,(1S,2S)-2-[2-[[3-(1H-benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenylester, dihydrochloride (9CI); NNC 55-0396

Suppliers and Price of (1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • NNC 55-0396 dihydrochloride
  • 10mg
  • $ 602.00
  • TRC
  • NNC55-0396
  • 25mg
  • $ 450.00
  • Tocris
  • NNC55-0396dihydrochloride ≥98%(HPLC)
  • 10
  • $ 298.00
  • DC Chemicals
  • NNC55-0396 >98%
  • 100 mg
  • $ 400.00
  • Crysdot
  • NNC55-0396 98+%
  • 50mg
  • $ 396.00
  • Crysdot
  • NNC55-0396 98+%
  • 10mg
  • $ 126.00
  • ChemScene
  • NNC55-0396 99.24%
  • 5mg
  • $ 280.00
  • ChemScene
  • NNC55-0396 99.24%
  • 1mg
  • $ 140.00
  • Cayman Chemical
  • NNC 55-0396
  • 25mg
  • $ 595.00
  • Cayman Chemical
  • NNC 55-0396 ≥98%
  • 5mg
  • $ 163.00
Total 20 raw suppliers
Chemical Property of (1S,2S)-2-[2-[[3-(1H-BENZIMIDAZOL-2-YL)PROPYL]METHYLAMINO]ETHYL]-6-FLUORO-1,2,3,4-TETRAHYDRO-1-(1-METHYLETHYL)-2-NAPHTHALENYL CYCLOPROPANECARBOXYLATE DIHYDROCHLORIDE
Chemical Property:
  • Vapor Pressure:1.23E-20mmHg at 25°C 
  • Boiling Point:713.8°Cat760mmHg 
  • Flash Point:385.5°C 
  • PSA：58.22000 
  • Density:g/cm3 
  • LogP:7.63850 
  • Storage Temp.:Desiccate at RT 
  • Solubility.:DMSO (Slightly), Water (Slightly) 
Purity/Quality:

99% *data from raw suppliers

NNC 55-0396 dihydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Description NNC 55-0396 is a selective inhibitor of T-type calcium channels that blocks Cav3.1 in stably expressing HEK293 cells (IC50 = 6.8 μM) with no discernible effect on high voltage-activated (L-type) channels in INS-1 cells up to a concentration of 100 μM. NNC 55-0396 suppresses tremor in two murine models, the GABAA α1-null (20 mg/kg) and harmaline-induced (12.5 mg/kg) tremor models, and was better tolerated than mibefradil . In arterial smooth muscle cells, NCC 55-0396 (IC50 = 80 nM) inhibits voltage-dependent K+ channels but does not affect their voltage sensitivity. NNC 55-0396 (1-5 μM) also suppresses angiogenesis in vitro by inhibiting hypoxia-inducible factor-1α activity, and it slows tumor growth of flank xenografts of U87MG cells in mice when administered at 20 mg/kg.
  • Uses NNC 55-0396 is a calcium channel protein inhibitor.
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