(2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate

Base Information

• Chemical Name: (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate
• CAS No.: 1252633-27-4
• Molecular Formula: C₁₇H₂₁ClFNO₆S
• Molecular Weight: 421.874

Synonyms:(2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate

Chemical Property of (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate

Chemical Property:

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Technology Process of (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate

There total 2 articles about (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-tert-butyl 2-methyl (2S,4R)-4-[(2-chloro-4-fluorophenyl)sulfanyl]pyrrolidine-1,2-dicarboxylate (1252633-26-3) → (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate (1252633-27-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃;

Reference yield:

→ (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate (1252633-27-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; Inert atmosphere;

Reference yield: 78.0%

piperidine (110-89-4) + (2S,4R)-1-tert-butyl 2-methyl 4-(2-chloro-4-fluorophenylsulfonyl)pyrrolidine-1,2-dicarboxylate (1252633-27-4) → (2S,4R)-4-(2-Chloro-4-piperidin-1-yl-benzenesulfonyl)-pyrrolidine-1,2-dicarboxylic Acid 1-tert.-butyl Ester 2-methyl Ester (1252633-31-0)

Guidance literature:

With caesium carbonate; In ISOPROPYLAMIDE; at 20 - 140 ℃; Microwave irradiation;

upstream raw materials:

1-tert-butyl 2-methyl (2S,4R)-4-[(2-chloro-4-fluorophenyl)sulfanyl]pyrrolidine-1,2-dicarboxylate

Downstream raw materials:

(2S,4R)-4-(2-Chloro-4-piperidin-1-yl-benzenesulfonyl)-pyrrolidine-1,2-dicarboxylic Acid 1-tert.-butyl Ester 2-methyl Ester

(2S,4R)-4-(2-chloro-4-pyrazol-1-ylbenzenesulfonyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

(2S,4R)-4-[2-Chloro-4-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzenesulfonyl]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl Ester 2-methyl Ester

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