(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Base Information

Chemical Name:(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone
CAS No.:1454290-33-5
Molecular Formula:C₂₂H₂₁ClF₂N₄OS
Molecular Weight:462.951
Hs Code.:

Synonyms:(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Chemical Property of (2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

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Technology Process of (2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

There total 5 articles about (2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1454291-19-0
(±)5-chloro-N-((4,4-difluoropiperidin-2-yl)methyl)pyridin-2-amine

: 13743-09-4
2-methyl-5-phenyl-1,3-thiazole-4-carboxylic acid

: 1454290-33-5
(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: 2-methyl-5-phenyl-1,3-thiazole-4-carboxylic acid; With ethylene dichloride hydrochloride; benzotriazol-1-ol; In dichloromethane; at 25 ℃; for 2h;

(±)5-chloro-N-((4,4-difluoropiperidin-2-yl)methyl)pyridin-2-amine; In dichloromethane; for 18h;

Reference yield:

: 1454291-08-7
(±) tert-butyl 2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidine-1-carboxylate

: 1454290-33-5
(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

2.1: benzotriazol-1-ol; ethylene dichloride hydrochloride / dichloromethane / 2 h / 25 °C

2.2: 18 h

With ethylene dichloride hydrochloride; benzotriazol-1-ol; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1454290-33-5
(2-(((5-chloropyridin-2-yl)amino)methyl)-4,4-difluoropiperidin-1-yl)(2-methyl-5-phenylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 4 h / -40 - -20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / diethyl ether / -78 - -40 °C

3.1: acetic acid / dichloromethane / 1.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

5.1: benzotriazol-1-ol; ethylene dichloride hydrochloride / dichloromethane / 2 h / 25 °C

5.2: 18 h

With ethylene dichloride hydrochloride; N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; sec.-butyllithium; benzotriazol-1-ol; acetic acid; trifluoroacetic acid; In diethyl ether; dichloromethane;