C₃₂H₂₅ClF₃N₇

Base Information

• Chemical Name: C₃₂H₂₅ClF₃N₇
• CAS No.: 1337567-25-5
• Molecular Formula: C₃₂H₂₅ClF₃N₇
• Molecular Weight: 600.046
• Mol file: 1337567-25-5.mol

Synonyms:C₃₂H₂₅ClF₃N₇

Chemical Property of C₃₂H₂₅ClF₃N₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₂₅ClF₃N₇

There total 8 articles about C₃₂H₂₅ClF₃N₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H23ClF3N7O2 (1337567-24-4) → C32H25ClF3N7 (1337567-25-5)

Guidance literature:

C₃₂H₂₃ClF₃N₇O₂; With tin(II) chloride dihdyrate; In 1,4-dioxane; ethanol; at 90 ℃; for 48h;

With potassium fluoride; water; In 1,4-dioxane; ethanol; at 20 ℃; for 1h;

Reference yield:

2-(2,3,6-trifluorophenyl)acetic acid (114152-23-7) → C32H25ClF3N7 (1337567-25-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 1 h / 20 °C

2.1: boron trifluoride diethyl etherate / methanol / 1.5 h / 100 °C / sealed tube

3.1: copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 160 °C

4.1: tin(II) chloride dihdyrate / 1,4-dioxane; ethanol / 48 h / 90 °C

4.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; tin(II) chloride dihdyrate; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol;

Reference yield:

methyl-2-bromo-5-chlorobenzoate (27007-53-0) → C32H25ClF3N7 (1337567-25-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.2: 1 h / 20 °C

2.1: boron trifluoride diethyl etherate / methanol / 1.5 h / 100 °C / sealed tube

3.1: copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 160 °C

4.1: tin(II) chloride dihdyrate / 1,4-dioxane; ethanol / 48 h / 90 °C

4.2: 1 h / 20 °C

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; tin(II) chloride dihdyrate; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol;

upstream raw materials:

2-(2,3,6-trifluorophenyl)acetic acid

methyl-2-bromo-5-chlorobenzoate

1-(2-bromo-5-chlorophenyl)-2-(2,3,6-trifluorophenyl)ethanone

C₁₉H₁₉N₅O₂S

Downstream raw materials:

C₃₄H₂₇ClF₃N₇O₂

methyl {4,6-diamino-2-[5-chloro-3-(2,3,6-trifluorobenzyl)-1H-indazol-1-yl]pyrimidin-5-yl}carbamate