(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Base Information

Chemical Name:(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone
CAS No.:745809-28-3
Molecular Formula:C₃₁H₄₀O₉Si
Molecular Weight:584.739
Hs Code.:

Synonyms:(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Suppliers and Price of (+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

There total 11 articles about (+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 745809-56-7
acetic acid 3-[2-(tert-butyl-dimethyl-silanyloxy)-2-(1-hydroxy-4-methoxy-5,8-bis-methoxymethoxy-naphthalen-2-yl)-ethyl]-5-methyl-phenyl ester

: 745809-28-3
(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; for 0.0833333h;
DOI:10.1021/jo049426c

Reference yield:

: 34946-83-3
2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone

: 745809-28-3
(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Guidance literature:: Multi-step reaction with 11 steps

1.1: 57 percent / sulfuric acid / 16 h

2.1: 2,6-lutidine

3.1: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

4.1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / -78 - 0 °C

5.1: triphenylphosphine / CH₂Cl₂ / 0.08 h

6.1: 0.37 g / n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

7.1: 99 percent / TBAF; acetic acid / tetrahydrofuran / 2 h

8.1: 98 percent / pyridine / 18 h / 23 °C

9.1: heptane / 14 h / 57 °C

9.2: 35 percent / air / heptane; ethyl acetate / 0.25 h

10.1: 89 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.08 h

With pyridine; 2,6-dimethylpyridine; n-butyllithium; oxalyl dichloride; ammonium cerium(IV) nitrate; sulfuric acid; tetrabutyl ammonium fluoride; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; n-heptane; dichloromethane; water; acetonitrile; 5.1: Swern oxidation / 10.1: Doetz benzannulation;
DOI:10.1021/jo049426c

Reference yield:

: 108-39-4
3-methyl-phenol

: 745809-28-3
(+)-2-[1-(tert-butyldimethylsilyloxy)-2-(3-acetoxy-5-methylphenyl)ethyl]-5,8-bis(methoxymethoxy)-[1,4]naphthoquinone

Guidance literature:: Multi-step reaction with 12 steps

1.1: 52 percent / Br₂ / acetic acid

2.1: 57 percent / sulfuric acid / 16 h

3.1: 2,6-lutidine

4.1: 92 percent / DDQ; buffer / CH₂Cl₂; H₂O / 1 h / pH 7

5.1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / 0.5 h / -78 - 0 °C

6.1: triphenylphosphine / CH₂Cl₂ / 0.08 h

7.1: 0.37 g / n-BuLi / tetrahydrofuran / 0.25 h / -78 °C

8.1: 99 percent / TBAF; acetic acid / tetrahydrofuran / 2 h

9.1: 98 percent / pyridine / 18 h / 23 °C

10.1: heptane / 14 h / 57 °C

10.2: 35 percent / air / heptane; ethyl acetate / 0.25 h

11.1: 89 percent / ceric ammonium nitrate / acetonitrile; H₂O / 0.08 h

With pyridine; 2,6-dimethylpyridine; n-butyllithium; oxalyl dichloride; ammonium cerium(IV) nitrate; sulfuric acid; tetrabutyl ammonium fluoride; bromine; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; n-heptane; dichloromethane; water; acetic acid; acetonitrile; 6.1: Swern oxidation / 11.1: Doetz benzannulation;
DOI:10.1021/jo049426c