6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Base Information

Chemical Name:6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one
CAS No.:1201674-74-9
Molecular Formula:C₂₂H₂₈N₆O
Molecular Weight:392.504
Hs Code.:

Synonyms:6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

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Chemical Property of 6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

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Technology Process of 6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

There total 8 articles about 6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1201676-06-3
4-[6-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl]piperazine-1-carboxylic acid tert-butyl ester

: 1201674-74-9
6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Guidance literature:: 4-[6-(2-cyclohexylaminopyridin-4-yl)-1-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yl]piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With triethylamine; In dichloromethane;

Reference yield:

: 1201676-03-0
4,6-dichloro-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

: 1201674-74-9
6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / 1,4-dioxane / 40 h / 120 °C

2: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With triethylamine; cesium fluoride; trifluoroacetic acid; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane;

Reference yield:

: 1201674-99-8
2-cyclohexylamino-4-iodopyridine

: 1201674-74-9
6-(2-cyclohexylaminopyridin-4-yl)-4-piperazin-1-yl-2,3-dihydropyrrolo[3,4-c]pyridin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With cesium fluoride; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; toluene;