Technology Process of (S)-1-((2S,3S)-3-phenethyloxiran-2-yl)but-3-en-1-ol
There total 4 articles about (S)-1-((2S,3S)-3-phenethyloxiran-2-yl)but-3-en-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate;
In
dichloromethane;
at -20 ℃;
for 5h;
optical yield given as %ee;
Molecular sieve;
DOI:10.1016/j.tetasy.2010.11.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dichloromethane / 8 h / 20 °C
2: diisobutylaluminium hydride / toluene / 0.5 h / -78 °C
3: ammonium chloride; zinc / tetrahydrofuran / 3 h / 0 - 20 °C
4: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / 5 h / -20 °C / Molecular sieve
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; diisobutylaluminium hydride; ammonium chloride; zinc;
In
tetrahydrofuran; dichloromethane; toluene;
1: Wittig reaction / 4: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2010.11.003
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ammonium chloride; zinc / tetrahydrofuran / 3 h / 0 - 20 °C
2: titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate / dichloromethane / 5 h / -20 °C / Molecular sieve
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; ammonium chloride; zinc;
In
tetrahydrofuran; dichloromethane;
2: Sharpless epoxidation;
DOI:10.1016/j.tetasy.2010.11.003
