tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

Base Information

Chemical Name:tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate
CAS No.:911224-83-4
Molecular Formula:C₂₅H₃₅NO₂
Molecular Weight:381.558
Hs Code.:

Synonyms:tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

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Technology Process of tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

There total 1 articles about tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 87776-18-9
(2E)-tert-butyl 4-methylpent-2-enoate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 911224-83-4
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1016/j.tetasy.2006.05.008

Reference yield: 44.0%

: 911224-83-4
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

: 2564-83-2,45842-10-2,126517-51-9,25657-03-8,26933-82-4,54637-06-8,64104-42-3
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical

: (2S,3S)-tert-butyl 3-{N-benzyl-N-[(S)-1-(naphthalen-1-yl)ethyl]amino}-3-phenyl-2-[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]propanoate

Guidance literature:: tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.833333h; Inert atmosphere; Schlenk technique;

2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; With ferrocenium hexafluorophosphate; In tetrahydrofuran; hexane; at -78 ℃; diastereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201801139

Reference yield:

: 911224-83-4
tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

: 863309-36-8
2,2,6,6-tetramethylpiperidine-1-oxoammonium hexafluorophosphate

: (2R,3R)-tert-butyl 3-[N-benzyl-N-((R)-1-phenylethyl)amino]-2-[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]-4-methylpentanoate

: (2S,3R)-tert-butyl 3-[N-benzyl-N-((R)-1-phenylethyl)amino]-2-[(2,2,6,6-tetramethylpiperidin-1-yl)oxy]-4-methylpentanoate

Guidance literature:: tert-butyl (3S,αR)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 ℃; for 0.833333h; Inert atmosphere; Schlenk technique;

2,2,6,6-tetramethylpiperidine-1-oxoammonium hexafluorophosphate; With ferrocene; In tetrahydrofuran; hexane; at -78 ℃; Overall yield = 52 %; diastereoselective reaction; Inert atmosphere; Schlenk technique;
DOI:10.1002/ejoc.201801139