N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

Base Information

Chemical Name:N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine
CAS No.:1578483-78-9
Molecular Formula:C₂₃H₂₂N₈O
Molecular Weight:426.481
Hs Code.:

Synonyms:N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

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Chemical Property of N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

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Technology Process of N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

There total 4 articles about N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1400287-29-7
4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyaniline

: 1578484-39-5
2-chloro-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidine

: 1578483-78-9
N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

Guidance literature:: With palladium diacetate; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In N,N-dimethyl-formamide; at 160 ℃; for 2h; Microwave irradiation;

Reference yield:

: 211244-81-4
2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1578483-78-9
N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 16 h / 80 °C / Inert atmosphere

2: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; methanol / 0.5 h / 150 °C / Microwave irradiation

3: sulfuryl dichloride / acetonitrile; dichloromethane / 0.33 h / 0 °C

4: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 160 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; palladium diacetate; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; cesium fluoride; trichlorophosphate; In methanol; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1578484-40-8
7-(1-methyl-1H-pyrazol-4-yl)-2-(methylthio)pyrido[2,3-d]pyrimidine

: 1578483-78-9
N-(4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)-7-(1-methyl-1H-pyrazol-4-yl)pyrido[2,3-d]pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuryl dichloride / acetonitrile; dichloromethane / 0.33 h / 0 °C

2: (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; palladium diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 160 °C / Microwave irradiation

With sulfuryl dichloride; palladium diacetate; potassium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;