2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

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Chemical Name:2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester
CAS No.:801239-52-1
Molecular Formula:C₄₀H₅₇N₅O₉S
Molecular Weight:783.987
Hs Code.:

2-(benzenesulfonyl-{2-[2-(3-<i>tert</i>-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid <i>tert</i>-butyl ester

Synonyms:2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

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Chemical Property of 2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

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Technology Process of 2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

There total 6 articles about 2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: tert-butyl N-[3-[2-(2-hydroxyethoxy)ethoxy]propyl]carbamate

: 801239-95-2
2-benzenesulfonylamino-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

: 801239-52-1
2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 ℃; for 16h;
DOI:10.1021/jm049666k

Reference yield:

: 10602-03-6
ethyl 4-ethynylbenzoate

: 801239-52-1
2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / Pd(PPh₃)2Cl₂; CuI; Et₃N / various solvent(s) / 16 h / 90 °C

2: H₂ / Pd/C / ethanol / 16 h

3: 260 mg / aq. NaOH / methanol; tetrahydrofuran / 16 h / 20 °C

4: 76 percent / EDC; HOBT; NMM / dimethylformamide / 16 h / 20 °C

5: 81 percent / PPh₃; DIAD / CH₂Cl₂ / 16 h / 0 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; di-isopropyl azodicarboxylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Sonogashira coupling / 5: Mitsunobu reaction;
DOI:10.1021/jm049666k

Reference yield:

: 89026-79-9
2-bromo-6-(methylamino)pyridine

: 801239-52-1
2-(benzenesulfonyl-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethyl}-amino)-3-{4-[2-(6-methylamino-pyridin-2-yl)-ethyl]-benzoylamino}-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / Pd(PPh₃)2Cl₂; CuI; Et₃N / various solvent(s) / 16 h / 90 °C

2: H₂ / Pd/C / ethanol / 16 h

3: 260 mg / aq. NaOH / methanol; tetrahydrofuran / 16 h / 20 °C

4: 76 percent / EDC; HOBT; NMM / dimethylformamide / 16 h / 20 °C

5: 81 percent / PPh₃; DIAD / CH₂Cl₂ / 16 h / 0 °C

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; di-isopropyl azodicarboxylate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Sonogashira coupling / 5: Mitsunobu reaction;
DOI:10.1021/jm049666k