ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

Base Information

Chemical Name:ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate
CAS No.:1065081-71-1
Molecular Formula:C₁₈H₁₆F₃N₃O₂
Molecular Weight:363.339
Hs Code.:

Synonyms:ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

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Chemical Property of ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

Chemical Property:

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Technology Process of ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

There total 3 articles about ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₁F₃O₂

: 6994-25-8,103259-35-4,19750-02-8
3-amino-4-pyrazolecarboxylic acid ethyl ester

: 1065081-71-1
ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: With hydrogenchloride; In ethanol; water; at 50 ℃; for 1h;

Reference yield:

: 1065081-51-7
dimethyl {1-[3-(trifluoromethyl)phenyl]ethyl}malonate

: 1065081-71-1
ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / hexanes; diethyl ether / 2 h / -78 °C

1.2: -78 - 0 °C

2.1: hydrogenchloride / ethanol; water / 1 h / 50 °C

With hydrogenchloride; diisobutylaluminium hydride; In hexanes; diethyl ether; ethanol; water;

Reference yield:

: 59770-96-6,68120-41-2
1-(1-bromoethyl)-3-(trifluoromethyl)benzene

: 1065081-71-1
ethyl 6-{1-[3-(trifluoromethyl)phenyl]ethyl}pyrazolo[1,5-a]pyrimidine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

2.1: diisobutylaluminium hydride / hexanes; diethyl ether / 2 h / -78 °C

2.2: -78 - 0 °C

3.1: hydrogenchloride / ethanol; water / 1 h / 50 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexanes; diethyl ether; ethanol; water;