Technology Process of 5-(2-(4-fluoro-2-methoxyphenoxy)-4-(perfluoroethyl)benzamido)picolinic acid
There total 5 articles about 5-(2-(4-fluoro-2-methoxyphenoxy)-4-(perfluoroethyl)benzamido)picolinic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol;
at 40 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper / dimethyl sulfoxide / 48.5 h / 100 - 120 °C / Inert atmosphere
2: HATU; 4-methyl-morpholine / 16 h / 25 °C
3: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 90 °C
4: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one; methanol / 1 h / 40 °C
With
4-methyl-morpholine; water; copper; caesium carbonate; HATU; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 1 h / 90 °C
2: sodium hydroxide; water / 1-methyl-pyrrolidin-2-one; methanol / 1 h / 40 °C
With
water; caesium carbonate; sodium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol;