(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester
CAS No.:545363-32-4
Molecular Formula:C₃₄H₄₁N₃O₁₁S
Molecular Weight:699.779
Hs Code.:

(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Synonyms:(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Suppliers and Price of (11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

There total 20 articles about (11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

: 545363-04-0
(1'Z)-(3'S)-2-(3'-dimethoxymethyl-3'-ethoxycarbonylmethyl-6'-hydroxy-hex-1'-enyl)-6,7-dimethoxy-3-[2-(2-nitro-benzenesulfonylamino)-ethyl]-indole-1-carboxylic acid tert-butyl ester

: 545363-32-4
(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Guidance literature:: (1'Z)-(3'S)-2-(3'-dimethoxymethyl-3'-ethoxycarbonylmethyl-6'-hydroxy-hex-1'-enyl)-6,7-dimethoxy-3-[2-(2-nitro-benzenesulfonylamino)-ethyl]-indole-1-carboxylic acid tert-butyl ester; With trimethylsilyl bromide; In dichloromethane; at -70 ℃; for 0.25h;

With phosphate buffer; In tetrahydrofuran; dichloromethane; pH=7.0;
DOI:10.1021/ol034445e

Reference yield: 91.9%

: 545363-06-2
(11S)-(12Z)-11-dimethoxymethyl-11-ethoxycarbonylmethyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

: 545363-32-4
(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at -70 ℃;
DOI:10.1016/j.tet.2003.09.005

Reference yield:

: 55149-84-3
2-nitroveratraldehyde

: 545363-32-4
(11S)-(12Z)-11-ethoxycarbonylmethyl-11-formyl-1,2-dimethoxy-7-(2-nitro-benzenesulfonyl)-6,7,8,9,10,11-hexahydro-5H-7,14-diaza-cycloundeca[a]indene-14-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 14 steps

1.1: 80.5 percent / n-Bu₄N⁽¹⁺⁾*I^(1-); NaOH / H₂O; CH₂Cl₂ / 0.42 h / 5 °C

2.1: Zn; AcOH / CH₂Cl₂ / 10 - 20 °C

3.1: Ac₂O / CH₂Cl₂ / 0.17 h / 5 °C

4.1: 63.3 percent / pyridine; phosphopus oxychloride / CH₂Cl₂ / 1.17 h / 5 °C

5.1: Bu₃SnH; AIBN / acetonitrile / 1.5 h / Heating

5.2: 84.6 percent / I₂ / acetonitrile / 1 h / 20 °C

6.1: 12.5 g / DIBAL / toluene / 0.83 h / 5 °C

7.1: 85.3 percent / pyridine / 0.5 h

8.1: 78 percent / triethylamine; Pd(PPh₃)4; CuI / 2 h / 70 °C

9.1: 94.3 percent / 4-(dimethylamino)pyridine / acetonitrile / 0.25 h / 20 °C

10.1: 97 percent / H₂ / Pd on carbon / ethanol / 3.5 h / 20 °C / 760 Torr

11.1: 96.2 percent / K₂CO₃ / methanol / 1 h / 20 °C

12.1: 92.7 percent / PPh₃; DEAD / benzene; toluene / 0.08 h / 20 °C

13.1: 93 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

14.1: TMSBr / CH₂Cl₂ / 0.25 h / -70 °C

14.2: 91.9 percent / phosphate buffer / CH₂Cl₂; tetrahydrofuran / pH 7.0

With pyridine; dmap; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); trimethylsilyl bromide; tetrabutyl ammonium fluoride; hydrogen; tri-n-butyl-tin hydride; acetic anhydride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; zinc; diethylazodicarboxylate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene; acetonitrile; benzene; 1.1: Wittig olefination / 8.1: Sonogashira coupling / 12.1: Mitsunobu reaction;
DOI:10.1021/ol034445e