4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

Base Information

Chemical Name:4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile
CAS No.:1331740-69-2
Molecular Formula:C₁₈H₁₅BrN₄O
Molecular Weight:383.247
Hs Code.:

Synonyms:4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

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Chemical Property of 4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

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Technology Process of 4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

There total 6 articles about 4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1331740-68-1
4-(3-(3-bromo-4-(triisopropylsilyloxy)phenyl)-1-(1H-1,2,4-triazol-1-yl)-propyl)benzonitrile

: 1331740-69-2
4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.25h;
DOI:10.1002/cmdc.201100145

Reference yield:

: 1331740-66-9
2-(3-bromo-4-(triisopropylsilyloxy)phenyl)ethanol

: 1331740-69-2
4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole; bromine; triphenylphosphine / diethyl ether; acetonitrile / 3 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 20 °C

With 1H-imidazole; n-butyllithium; tetrabutyl ammonium fluoride; bromine; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1002/cmdc.201100145

Reference yield:

: 1331740-65-8
methyl 2-(3-bromo-4-(triisopropylsilyloxy)phenyl)acetate

: 1331740-69-2
4-(3-(3-bromo-4-hydroxyphenyl)-1-(1H-1,2,4-triazol-1-yl)propyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium borohydride; Trimethyl borate / diethyl ether / 48 h / 20 °C

2.1: 1H-imidazole; bromine; triphenylphosphine / diethyl ether; acetonitrile / 3 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h / 20 °C

With 1H-imidazole; lithium borohydride; n-butyllithium; Trimethyl borate; tetrabutyl ammonium fluoride; bromine; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1002/cmdc.201100145