(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

Base Information

Chemical Name:(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide
CAS No.:701267-20-1
Molecular Formula:C₁₈H₁₆F₂N₂O₃
Molecular Weight:346.333
Hs Code.:

Synonyms:(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

Chemical Property:

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Technology Process of (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

There total 5 articles about (RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 701266-74-2
(RS)-[2,6-difluoro-3-hydroxy-phenyl]-ethoxy-acetic acid

: 15996-76-6
4-cyanobenzylamine hydrochloride

: 701267-20-1
(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 50.5h;

Reference yield:

: 701266-71-9
tert-butyl-(2,4-difluoro-phenoxy)-diphenyl-silane

: 701267-20-1
(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine / 1,2-dimethoxyethane; hexane / 2 h / -70 °C

1.2: 4 h / -70 - 0 °C

2.1: silver(l) oxide / toluene / 68 h / 90 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 65 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 50.5 h / 0 - 20 °C

With lithium hydroxide; n-butyllithium; N,N,N',N'',N'''-pentamethyldiethylenetriamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; silver(l) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); 1,2-dimethoxyethane; hexane; water; toluene;

Reference yield:

: 701266-72-0
(RS)-[3-(tert-butyl-diphenyl-silanyloxy)-2,6-difluoro-phenyl]-hydroxy-acetic acid ethyl ester

: 701267-20-1
(RS)-N-(4-cyano-benzyl)-2-(2,6-difluoro-3-hydroxy-phenyl)-2-ethoxy-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: silver(l) oxide / toluene / 68 h / 90 °C

2: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 65 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / DMF (N,N-dimethyl-formamide) / 50.5 h / 0 - 20 °C

With lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; silver(l) oxide; In tetrahydrofuran; methanol; DMF (N,N-dimethyl-formamide); water; toluene;