4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

Base Information

Chemical Name:4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid
CAS No.:1048669-02-8
Molecular Formula:C₂₂H₂₅N₃O₃S
Molecular Weight:411.525
Hs Code.:

Synonyms:4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

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Chemical Property of 4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

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Technology Process of 4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

There total 6 articles about 4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1048669-03-9
methyl 4-[4-(2-adamantylcarbamoyl)-5-methylsulfanylpyrazol-1-yl]benzoate

: 1048669-02-8
4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 60 ℃; for 18h;
DOI:10.1021/jm301252n

Reference yield:

: 1048669-27-7
tert-butyl 5-amino-1-(4-methoxycarbonylphenyl)pyrazole-4-carboxylate

: 1048669-02-8
4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 65 °C

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: sodium hydroxide / methanol; water / 18 h / 60 °C

With tert.-butylnitrite; sodium hexamethyldisilazane; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; copper dichloride; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm301252n

Reference yield:

: 1048669-89-1
1-(4-(methoxycarbonyl)phenyl)-5-(methylthio)-1H-pyrazole-4-carboxylic acid

: 1048669-02-8
4-[4-(2-adamantylcarbamoyl)-5-methylsulfanyI-pyrazol-1-yl]benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 20 °C

2: sodium hydroxide / methanol; water / 18 h / 60 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm301252n