{(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester
• CAS No.: 1025877-05-7
• Molecular Formula: C₄₂H₅₅FN₄O₆
• Molecular Weight: 730.92

Synonyms:{(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester

Chemical Property of {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester

There total 6 articles about {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-5-(tert-butyloxycarbonylamino)-5,3-dimethyl-2-hexenoic acid (193085-35-7) + N-[1-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-N-methyl-2-methylamino-3-naphthalen-2-yl-propionamide (1026292-85-2) → {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester (1025877-05-7)

Guidance literature:

(2E)-5-(tert-butyloxycarbonylamino)-5,3-dimethyl-2-hexenoic acid; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 0.333333h;

N-[1-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-N-methyl-2-methylamino-3-naphthalen-2-yl-propionamide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

DOI:10.1016/S0223-5234(02)01370-3

Reference yield:

4-HYDROXYPIPERIDINE (5382-16-1) → {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester (1025877-05-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 72 h / 0 - 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 °C

3.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

3.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 72 h / 0 - 20 °C

4.1: trifluoroacetic acid / CH₂Cl₂ / 0.83 h / 0 °C

5.1: HOAt; EDAC*HCl / CH₂Cl₂ / 0.33 h / 0 °C

5.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(02)01370-3

Reference yield:

(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(4-fluorophenyl)propionic acid (193085-53-9) → {(E)-4-[((R)-1-{[(R)-1-(4-Fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-methyl-carbamoyl}-2-naphthalen-2-yl-ethyl)-methyl-carbamoyl]-1,1,3-trimethyl-but-3-enyl}-carbamic acid tert-butyl ester (1025877-05-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

1.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 72 h / 0 - 20 °C

2.1: trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 0 °C

3.1: HOAt; EDAC*HCl / CH₂Cl₂; dimethylformamide / 0.33 h / 0 °C

3.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 72 h / 0 - 20 °C

4.1: trifluoroacetic acid / CH₂Cl₂ / 0.83 h / 0 °C

5.1: HOAt; EDAC*HCl / CH₂Cl₂ / 0.33 h / 0 °C

5.2: iPr₂NEt / CH₂Cl₂; dimethylformamide / 16 h / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(02)01370-3

upstream raw materials:

(2E)-5-(tert-butyloxycarbonylamino)-5,3-dimethyl-2-hexenoic acid

N-[1-(4-fluoro-benzyl)-2-(4-hydroxy-piperidin-1-yl)-2-oxo-ethyl]-N-methyl-2-methylamino-3-naphthalen-2-yl-propionamide

4-HYDROXYPIPERIDINE

(2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(4-fluorophenyl)propionic acid

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