4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

Base Information

Chemical Name:4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide
CAS No.:82099-00-1
Molecular Formula:C₂₅H₂₇N₃O₃S₂
Molecular Weight:481.64
Hs Code.:

Synonyms:4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

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Chemical Property of 4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

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Technology Process of 4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

There total 7 articles about 4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

: 82098-79-1
Naphthalene-2-sulfonic acid [3-(4-cyano-phenyl)-1-(pyrrolidine-1-carbonyl)-propyl]-amide

: 82099-00-1
4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

Guidance literature:: With TEA; hydrogen sulfide; In pyridine; Ambient temperature;

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 82099-00-1
4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / H₂ / Raney-nickel / methanol / Ambient temperature

2: 1.) NaNO₂/conc. HCl; 2.) CuCN/NaCN / 1.) H₂O, 0-5 deg C; 2.) benzene, 0-5 deg C, 30 min; room temp., 4 h

3: 63 percent / PBr₃ / CHCl₃ / 1.5 h / Heating

4: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

6: 98 percent / benzene / Ambient temperature

7: 70.5 percent / H₂S (gas), TEA / pyridine / Ambient temperature

With hydrogenchloride; TEA; hydrogen sulfide; sodium cyanide; hydrogen; sodium; phosphorus tribromide; potassium iodide; sodium nitrite; nickel; In pyridine; methanol; chloroform; benzene;

Reference yield:

: 72054-56-9
4-(2-bromoethyl)benzonitrile

: 82099-00-1
4-[3-(Naphthalene-2-sulfonylamino)-4-oxo-4-pyrrolidin-1-yl-butyl]-thiobenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KI; 2.) Na / 1.) EtOH, reflux; 2.) EtOH, reflux, 5 h

3: 98 percent / benzene / Ambient temperature

4: 70.5 percent / H₂S (gas), TEA / pyridine / Ambient temperature

With TEA; hydrogen sulfide; sodium; potassium iodide; In pyridine; benzene;