N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

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Chemical Name:N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate
CAS No.:1607592-52-8
Molecular Formula:C₂HF₃O₂*C₂₀H₂₇N₅O₂S
Molecular Weight:515.557
Hs Code.:

Synonyms:N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

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Chemical Property of N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

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Technology Process of N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

There total 7 articles about N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate)

: 76-05-1
trifluoroacetic acid

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 1607592-52-8
N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

Guidance literature:: (1R)-1-{1-[trans-4-(aminomethyl)cyclohexyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-2-yl}ethanol bis(trifluoroacetate); N,N-Dimethylcarbamoyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

trifluoroacetic acid; In dichloromethane; water; acetonitrile;

Reference yield:

: 69627-02-7,107818-20-2
thieno[3,2-b]pyridin-7-ol

: 1607592-52-8
N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutylammonium nitrate / dichloromethane / -5 °C

1.2: -5 - 20 °C

2.1: trichlorophosphate / 1 h / Reflux

3.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

5.1: triethyloxonium fluoroborate / tetrahydrofuran / 20 °C

5.2: 2 h / 85 °C

6.1: dichloromethane / 1 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; tetrabutylammonium nitrate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;

Reference yield:

: 110651-92-8
7-chloro-6-nitrothieno[3,2-b]pyridine

: 1607592-52-8
N'-[(trans-4-{2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-d]thieno[3,2-b]pyridin-1-yl}cyclohexyl)methyl]-N,N-dimethylurea trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / isopropyl alcohol / 2 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

3.1: triethyloxonium fluoroborate / tetrahydrofuran / 20 °C

3.2: 2 h / 85 °C

4.1: dichloromethane / 1 h / 20 °C

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triethyloxonium fluoroborate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;