methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

Base Information

Chemical Name:methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate
CAS No.:109065-01-2
Molecular Formula:C₄₈H₆₄F₂N₄O₈
Molecular Weight:863.055
Hs Code.:

methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

Synonyms:methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

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Chemical Property of methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

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Technology Process of methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

There total 1 articles about methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 13122-90-2
Boc-Phe-Phe-OH

: (E)-(2R,5S)-5-((3R,4S)-4-Amino-2,2-difluoro-3-hydroxy-6-methyl-heptanoylamino)-2-benzyl-7-methyl-oct-3-enoic acid methyl ester; compound with trifluoro-acetic acid

: 109065-01-2
methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

Guidance literature:: With diethylphosphoryl cyanide; triethylamine; In N,N-dimethyl-formamide; at 4 ℃;
DOI:10.1021/jm00392a016

Reference yield: 50.1%

: 109065-01-2
methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3(R)-hydroxy-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

: 109065-02-3
methyl 5(S)-{[4(S)-({[N-(tert-butyloxycarbonyl)-L-phenylalanyl]-L-phenylalanyl}amino)-2,2-difluoro-3-oxo-6-methylheptanoyl]amino}-7-methyl-2(R)-(phenylmethyl)-3-trans-octenoate

Guidance literature:: With dichloro-acetic acid; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; toluene; Ambient temperature;
DOI:10.1021/jm00392a016