Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6b)-

Base Information

• Chemical Name: Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6b)-
• CAS No.: 16008-33-6
• Molecular Formula: C18H21 N O3
• Molecular Weight: 299.37
• Mol file: 16008-33-6.mol

Synonyms:Isoneopine(7CI); Morphinan-6b-ol, 8,14-didehydro-4,5a-epoxy-3-methoxy-17-methyl- (8CI); Isoneopin

Chemical Property of Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6b)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6b)-

There total 11 articles about Morphinan-6-ol,8,14-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5a,6b)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+)-14β-bromocodeinone (5140-31-8) → ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6β-ol (738-91-0) + isoneopine (16008-33-6) + Neopin (467-14-1)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

(+)-14β-bromocodeine (4675-05-2) → ent-4,5β-epoxy-3-methoxy-17-methyl-hasuban-7-en-6β-ol (738-91-0) + isoneopine (16008-33-6) + Neopin (467-14-1)

Guidance literature:

With sodium tetrahydroborate;

Reference yield:

N-nororipavine hydrochloride (850-57-7) → isoneopine (16008-33-6) + 5,6,8,9-tetrahydro-2-methoxy-7-methyl-dibenzazonin-1,12-diol + Neopin (467-14-1) + codeine (76-57-3)

Guidance literature:

With sodium tetrahydroborate; trifluoroacetic acid; Yield given. Multistep reaction. Yields of byproduct given; 1.) 0.5 h, r.t.; 2.) MeOH, 0.5 h, r.t.;

DOI:10.1016/S0031-9422(00)82630-8

upstream raw materials:

(+)-14β-bromocodeinone

(+)-14β-bromocodeine

N-nororipavine hydrochloride

Thebaine

Downstream raw materials:

Acetylisoneopin

4,5α-epoxy-3-methoxy-17-methyl-6β-(toluene-4-sulfonyloxy)-morphin-8(14)-ene

4,5α-epoxy-3-methoxy-17-methyl-6β-(toluene-4-sulfonyloxy)-(14α)-morphinan-8α-ol

6α-acetoxy-4,5α-epoxy-3-methoxy-17-methyl-8α-(toluene-4-sulfonyloxy)-morphinane