Benzenemethanol, 3-methoxy-5-nitro- (9CI)

Base Information

• Chemical Name: Benzenemethanol, 3-methoxy-5-nitro- (9CI)
• CAS No.: 354525-36-3
• Molecular Formula: C8H9 N O4
• Molecular Weight: 183.164
• Hs Code.: 2909499000
• Mol file: 354525-36-3.mol

Synonyms:(3-Methoxy-5-nitrophenyl)methanol;3-Methoxy-5-nitrobenzyl alcohol

Chemical Property of Benzenemethanol, 3-methoxy-5-nitro- (9CI)

Chemical Property:

• PSA: 75.28000
• LogP: 1.61890

Purity/Quality:

99% ^*data from raw suppliers

(3-Methoxy-5-nitrophenyl)methanol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenemethanol, 3-methoxy-5-nitro- (9CI)

There total 4 articles about Benzenemethanol, 3-methoxy-5-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methoxy-5-nitrobenzoic acid (78238-12-7) → (3-methoxy-5-nitrophenyl)methanol (354525-36-3)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

DOI:10.1039/c8md00212f

Reference yield: 68.0%

3-methoxy-5-nitrobenzoic acid methyl ester (78238-13-8) → (3-methoxy-5-nitrophenyl)methanol (354525-36-3)

Guidance literature:

3-methoxy-5-nitrobenzoic acid methyl ester; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃;

With water; In diethyl ether;

Reference yield:

3,5-dinitrobenzoic acid (99-34-3) → (3-methoxy-5-nitrophenyl)methanol (354525-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HMPA / 25 °C

2: BH₃ / tetrahydrofuran / 16 h / 0 - 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; borane; In tetrahydrofuran;

DOI:10.1021/jm0305974

upstream raw materials:

3-methoxy-5-nitrobenzoic acid

3,5-dinitrobenzoic acid

3-methoxy-5-nitrobenzoic acid methyl ester

methyl 3,5-dinitrobenzoate

Downstream raw materials:

1-(azidomethyl)-3-methoxy-5-nitrobenzene

3-Hydroxy-5-pentyl-anilin

Refernces

• 1、 Zhang, Niu-niu,Liu, Zhi-yong,Liang, Jie,Tang, Yun-xiang,Qian, Lu,Gao, Ya-min,Zhang, Tian-Yu,Zhang, Tian-yu,Yan, Ming. "Design, synthesis, and biological evaluation of m-amidophenol derivatives as a new class of antitubercular agents". supporting information. p. 1293 - 1304. Retrieved 2018/08/28.
• 2、 -. "PHENYL-UREA AND PHENYL-CARBAMATE DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION". Paragraph 0094. . Retrieved 2013/10/21.