N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

Base Information

Chemical Name:N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide
CAS No.:168079-73-0
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

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Chemical Property of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

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Technology Process of N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

There total 8 articles about N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 168079-72-9
2-chloro-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]acetamide

: 168079-73-0
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In dichloromethane;

Reference yield:

: 168078-58-8
10,11-dihydro-10(4-nitrobenzoyl)-5H-pyrrolo[2,1-c][1,4]benzodiazepine

: 168079-73-0
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / palladium-carbon / ethanol

2: dmap; triethylamine / dichloromethane

3: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / dichloromethane

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; triethylamine; hydrazine; palladium-carbon; In ethanol; dichloromethane;

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 168079-73-0
N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-4-morpholineacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / 2-pyrrole aldehyde; N,N-dimethyl-formamide; mineral oil

2: hydrogen / palladium-carbon / ethanol; ethyl acetate

3: triethylamine / dichloromethane

4: hydrazine / palladium-carbon / ethanol

5: dmap; triethylamine / dichloromethane

6: dichloromethane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

With sodium hydride; dmap; hydrogen; triethylamine; hydrazine; palladium-carbon; In 2-pyrrole aldehyde; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;