(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

Base Information

Chemical Name:(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone
CAS No.:936502-07-7
Molecular Formula:C₁₅H₁₉NO₄
Molecular Weight:277.32
Hs Code.:

Synonyms:(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

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Chemical Property of (3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

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Technology Process of (3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

There total 3 articles about (3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 936501-99-4
N-(p-methoxybenzyl)-N-((2S)-chloropropionyl)-L-Ala-OMe

: 936502-07-7
(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

Guidance literature:: With tert-butylimino-tri(pyrrolidino)phosphorane; In acetonitrile; at 20 ℃;
DOI:10.1021/ol070533d

Reference yield:

: N-(p-methoxybenzyl)-N-(2-chloropropionyl)-L-Ala-OMe

: 936502-07-7
(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

: (3R,4R)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

Guidance literature:: With tert-butylimino-tri(pyrrolidino)phosphorane; In acetonitrile; at 20 ℃; Title compound not separated from byproducts.;
DOI:10.1021/ol070533d

Reference yield:

: 209627-18-9
2-(4-methoxybenzylamino)propionic acid methyl ester

: 936502-07-7
(3S,4S)-1-(p-methoxybenzyl)-3,4-dimethyl-4-methoxycarbonyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / PyBrop; DIEA / CH₂Cl₂

2: 66 percent / BTPP / acetonitrile / 20 °C

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; tert-butylimino-tri(pyrrolidino)phosphorane; In dichloromethane; acetonitrile;
DOI:10.1021/ol070533d