[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine

Base Information

• Chemical Name: [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine
• CAS No.: 404574-03-4
• Molecular Formula: C₂₆H₃₀N₂O
• Molecular Weight: 386.537
• Mol file: 404574-03-4.mol

Synonyms:[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine

Chemical Property of [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine

There total 2 articles about [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl-but-3-enyl}]isoindole-1,3-dione (404574-01-2) → [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine (404574-03-4)

Guidance literature:

With methylamine; In ethanol; for 2.5h; at reflux;

DOI:10.1021/tx0101494

Reference yield:

(Z)-(+/-)-alpha-Hydroxytamoxifen (97170-41-7) → [2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine (404574-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / Ph₃P; diethylazodicarboxylate / tetrahydrofuran

2: 76 percent / methylamine / ethanol / 2.5 h / at reflux

With triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1021/tx0101494

Reference yield: 47.0%

[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl but-3-enyl}]amine (404574-03-4) + (2S,3R,5S)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-[2-fluoro-6-(2-trimethylsilanyl-ethoxy)-1,6-dihydro-purin-9-yl]-tetrahydro-furan-3-ol → 5'-O-(4,4'-dimethoxytrityl)-N2-[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl-but-3-enyl}]-2'-deoxyguanosine

Guidance literature:

With triethylamine; In dimethyl sulfoxide; at 75 ℃; for 120h;

DOI:10.1021/tx0101494

upstream raw materials:

2-[2-{(Z)-4-(4-(2-dimethylaminoethoxy)phenyl)-3,4-diphenyl-but-3-enyl}]isoindole-1,3-dione

(Z)-(+/-)-alpha-Hydroxytamoxifen