5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one

Base Information

• Chemical Name: 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one
• CAS No.: 1388221-68-8
• Molecular Formula: C₃₀H₂₅BrN₄O₄
• Molecular Weight: 585.457

Synonyms:5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one

Chemical Property of 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one

Chemical Property:

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Technology Process of 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one

There total 8 articles about 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-methoxy-2-(prop-2-ynyloxy)benzoyl)-1-o-tolylpyridin-2(1H)-one (1388221-47-3) + 3-bromobenzyl chloride (932-77-4) → 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one (1388221-68-8)

Guidance literature:

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In acetone; at 20 ℃; for 2.5h;

DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one (1388221-68-8)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium / diethyl ether / 0 °C

2: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

3: methanol / Reflux

4: iodine / dichloromethane

5: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

6: methanol / Reflux

7: potassium carbonate / dichloromethane / 6 h / 20 °C

8: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / acetone / 2.5 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; iodine; sodium; potassium carbonate; acetic acid; sodium L-ascorbate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; acetone; 5: |Heck Reaction;

DOI:10.1016/j.ejmech.2013.06.046

Reference yield:

ω-formyl-4'-methoxy-2'-hydroxyacetophenone (94719-81-0) → 5-(2-((1-(3-bromobenzyl)-1H-1,2,3-triazol-4-yl)methoxy)-4-methoxybenzoyl)-1-o-tolylpyridin-2(1H)-one (1388221-68-8)

Guidance literature:

Multi-step reaction with 7 steps

1: acetic acid; hydrogenchloride / water / 0.5 h / 100 °C

2: methanol / Reflux

3: iodine / dichloromethane

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate / water; tetrahydrofuran / 100 °C

5: methanol / Reflux

6: potassium carbonate / dichloromethane / 6 h / 20 °C

7: sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate / acetone / 2.5 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; copper(ll) sulfate pentahydrate; iodine; potassium carbonate; acetic acid; sodium L-ascorbate; In tetrahydrofuran; methanol; dichloromethane; water; acetone; 4: |Heck Reaction;

DOI:10.1016/j.ejmech.2013.06.046

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)ethanone

ω-formyl-4'-methoxy-2'-hydroxyacetophenone

5-hydroxy-7-methoxy-4H-chromen-4-one

C₁₅H₁₉NO₃

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