2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide

Base Information

• Chemical Name: 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide
• CAS No.: 909392-66-1
• Molecular Formula: C₂₀H₂₀BrN₃O₃
• Molecular Weight: 430.301

Synonyms:2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide

Chemical Property of 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide

Chemical Property:

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Technology Process of 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide

There total 4 articles about 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-N-isopropylacetamide (67863-05-2) → 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide (909392-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMP / 20 °C

2: ethanol / 75 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMP; ethanol;

DOI:10.1016/j.bmcl.2011.04.022

Reference yield:

5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide (909392-66-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMP / 20 °C

2: ethanol / 75 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In DMP; ethanol;

DOI:10.1016/j.bmcl.2011.04.022

Reference yield:

2-amino-5-bromo-N-[2-(isopropylamino)-2-oxoethyl]benzamide + ethyl 3-methoxybenzenecarboximidoate hydrochloride → 2-[6-bromo-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-N-isopropylacetamide (909392-66-1)

Guidance literature:

In ethanol; at 75 ℃;

DOI:10.1016/j.bmcl.2011.04.022

upstream raw materials:

2-amino-N-isopropylacetamide

5-Bromo-2-aminobenzoic acid

Downstream raw materials:

N-isopropyl-2-[2-(3-methoxyphenyl)-4-oxo-6-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-4H-quinazolin-3-yl]acetamide

C₃₀H₃₂N₄O₃

C₂₆H₂₄N₄O₄

2-[6-(5-formylfuran-2-yl)-2-(3-methoxyphenyl)-4-oxo-4H-quinazolin-3-yl]-isopropylacetamide

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