[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

Base Information

Chemical Name:[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid
CAS No.:1372187-46-6
Molecular Formula:C₁₈H₂₃Cl₂NO₅
Molecular Weight:404.29
Hs Code.:

Synonyms:[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

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Chemical Property of [(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

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Technology Process of [(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

There total 12 articles about [(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1372189-14-4
tert-butyl (6R,7R)-6-(2-amino-2-oxoethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate

: 1372187-46-6
[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

Guidance literature:: tert-butyl (6R,7R)-6-(2-amino-2-oxoethyl)-7-(3,4-dichlorophenyl)-1,4-oxazepane-4-carboxylate; With water; sodium hydroxide; In butan-1-ol; at 120 ℃; for 4.5h;

With hydrogenchloride; In water; butan-1-ol;

Reference yield:

: 6287-38-3
3,4-dichlorobenzaldehyde

: 1372187-46-6
[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile / 48 h / 10 - 35 °C

2.1: triethylamine / methanol / 72 h / 10 - 35 °C

3.1: calcium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 2 h / 35 °C / Cooling with ice

3.2: 0.5 h

4.1: 1H-imidazole / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

5.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

6.1: sodium t-butanolate / tetrahydrofuran / 2 h / 35 °C / Cooling with ice

7.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether; tetrahydrofuran / 3 h / -78 - 0 °C / Inert atmosphere

7.2: 2 h / -78 - 35 °C

8.1: carbonochloridic acid 1-chloro-ethyl ester / acetonitrile / 0.25 h / 10 - 35 °C

8.2: 18 h / 80 °C

8.3: 2 h / 35 °C / Cooling with ice

9.1: CHIRALPAK AD / hexane; ethanol / Resolution of racemate

10.1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

11.1: N,N-dimethyl-formamide / 80 °C

12.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 1.5 h / 10 - 35 °C

13.1: sodium hydroxide; water / butan-1-ol / 4.5 h / 120 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; aluminum (III) chloride; sodium tetrahydroborate; lithium aluminium tetrahydride; carbonochloridic acid 1-chloro-ethyl ester; water; dihydrogen peroxide; potassium carbonate; triethylamine; calcium chloride; sodium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 1372189-39-3
tert-butyl (6S,7R)-7-(3,4-dichlorophenyl)-6-(hydroxymethyl)-1,4-oxazepane-4-carboxylate

: 1372187-46-6
[(6R,7R)-4-(tert-butoxycarbonyl)-7-(3,4-dichlorophenyl)-1,4-oxazepan-6-yl]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 2 h / Cooling with ice

2: N,N-dimethyl-formamide / 80 °C

3: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 1.5 h / 10 - 35 °C

4: sodium hydroxide; water / butan-1-ol / 4.5 h / 120 °C

With water; dihydrogen peroxide; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; butan-1-ol;