4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

Base Information

Chemical Name:4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide
CAS No.:56892-87-6
Molecular Formula:C₁₅H₁₄N₁₀O
Molecular Weight:350.343
Hs Code.:

Synonyms:4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

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Chemical Property of 4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

Chemical Property:

Purity/Quality:

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MSDS Files:: SDS file from LookChem

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Technology Process of 4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

There total 5 articles about 4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 56892-87-6
4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 48h;
DOI:10.1021/jo010283t

Reference yield:

: 7532-09-4
methotrexate sodium salt

: 56892-87-6
4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / TRIS buffer; conc. HCl; ZnCl₂ / carboxypeptidase G / H₂O / 48 h / 38 °C / pH 7.2

2: 83 percent / diphenylphosphoryl azide; Et₃N / dimethylsulfoxide / 20 h

With hydrogenchloride; Tris buffer; diphenylphosphoranyl azide; triethylamine; zinc(II) chloride; carboxypeptidase G; In water; dimethyl sulfoxide; 1: Hydrolysis / 2: Substitution;
DOI:10.1021/ja971568j

Reference yield:

: 945-24-4
2,4-diamino-6-(hydroxymethyl)pteridine

: 56892-87-6
4-{[N-[(2,4-diamino-6-pteridinyl)methyl]-N-methyl]amino}benzoyl azide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Ph₃P; Br₂ / various solvent(s) / 20 °C

1.2: 70 percent / N,N-diisopropylethylamine / various solvent(s) / 30 h / 45 °C

2.1: 85 percent / diphenylphosphoryl azide; triethylamine / dimethylsulfoxide / 48 h / 20 °C

With diphenylphosphoranyl azide; bromine; triethylamine; triphenylphosphine; In dimethyl sulfoxide;
DOI:10.1021/jo010283t