1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Base Information

Chemical Name:1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene
CAS No.:218435-23-5
Molecular Formula:C₂₈H₅₁BrO₅Si₂
Molecular Weight:603.785
Hs Code.:

1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Synonyms:1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Suppliers and Price of 1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

There total 8 articles about 1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1034-49-7
(bromomethyl)triphenyl phosphonium bromide

: 218435-22-4
(3R,5R,6R)-3-(tert-Butyl-dimethyl-silanyloxy)-6-(4-methoxy-benzyloxy)-5-(2-trimethylsilanyl-ethoxymethoxy)-heptanal

: 218435-23-5
1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 0.666667h;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 218435-18-8
(4R,6R)-4-Hydroxy-6-[(R)-1-(4-methoxy-benzyloxy)-ethyl]-tetrahydro-pyran-2-one

: 218435-23-5
1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / imidazole / dimethylformamide / 20 h / Ambient temperature

2: 99 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

3: 85 percent / DIPEA / CH₂Cl₂ / 15 h / Ambient temperature

4: 94 percent / DIBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

5: 65 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.67 h / -78 - 20 °C

With 1H-imidazole; trimethylaluminum; sodium hexamethyldisilazane; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(98)00889-8

Reference yield:

: 218435-14-4
(3R,5R,6R)-3,5-Dihydroxy-6-(4-methoxy-benzyloxy)-heptanoic acid methyl ester

: 218435-23-5
1-[(E)-(1R,2R,4S)-7-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-1-methyl-2-(2-trimethylsilanyl-ethoxymethoxy)-hept-6-enyloxymethyl]-4-methoxy-benzene

Guidance literature:: Multi-step reaction with 7 steps

1: aq. NaOH / tetrahydrofuran / 0.08 h / Ambient temperature

2: benzene / 15 h / Heating

3: 74 percent / imidazole / dimethylformamide / 20 h / Ambient temperature

4: 99 percent / Me₃Al / hexane; benzene / 1 h / Ambient temperature

5: 85 percent / DIPEA / CH₂Cl₂ / 15 h / Ambient temperature

6: 94 percent / DIBAL-H / CH₂Cl₂; hexane / 1 h / -78 °C

7: 65 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.67 h / -78 - 20 °C

With 1H-imidazole; sodium hydroxide; trimethylaluminum; sodium hexamethyldisilazane; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(98)00889-8