C₂₇H₂₁BrN₄O₂

Base Information

Chemical Name:C₂₇H₂₁BrN₄O₂
CAS No.:1402170-42-6
Molecular Formula:C₂₇H₂₁BrN₄O₂
Molecular Weight:513.393
Hs Code.:

C<sub>27</sub>H<sub>21</sub>BrN<sub>4</sub>O<sub>2</sub>

Synonyms:C₂₇H₂₁BrN₄O₂

Suppliers and Price of C₂₇H₂₁BrN₄O₂

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₂₇H₂₁BrN₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₂₇H₂₁BrN₄O₂

There total 19 articles about C₂₇H₂₁BrN₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: C₃₃H₂₆BrN₅O₄Se

: 1402170-42-6
C₂₇H₂₁BrN₄O₂

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;
DOI:10.1002/anie.201204726

Reference yield:

: 1402170-29-9
C₂₇H₅₆N₂O₄Si₃

: 1402170-42-6
C₂₇H₂₁BrN₄O₂

Guidance literature:: Multi-step reaction with 17 steps

1: potassium carbonate / methanol / 1.5 h / 20 °C / Inert atmosphere

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triphenylphosphine; copper(l) iodide; N-butylamine / toluene / 1.17 h / Inert atmosphere; Reflux

3: sodium methylate / tetrahydrofuran; methanol / 0.5 h / 20 - 50 °C / Inert atmosphere

4: zinc; hydrogenchloride / water; methanol / 0.67 h / 20 °C / Reflux

5: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

6: zinc; ammonium chloride / ethanol / 0.33 h / 20 °C

7: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

8: camphor-10-sulfonic acid / methanol / 0.67 h / 20 - 50 °C

9: diamide; tributylphosphine / toluene / 1.17 h / 20 °C / Inert atmosphere; Reflux

10: mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

11: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

12: caesium carbonate / tetrahydrofuran; acetonitrile / 1 h / 20 - 50 °C

13: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

14: tributylphosphine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

15: trifluorormethanesulfonic acid / dichloromethane / 0.33 h / -78 - 0 °C / Inert atmosphere

16: dmap; triethylamine / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

17: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; tributylphosphine; trifluorormethanesulfonic acid; diamide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; potassium carbonate; ammonium chloride; caesium carbonate; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-butylamine; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/anie.201204726

Reference yield:

: 1402170-31-3
C₄₁H₆₈BrN₃O₅Si₃

: 1402170-42-6
C₂₇H₂₁BrN₄O₂

Guidance literature:: Multi-step reaction with 15 steps

1: sodium methylate / tetrahydrofuran; methanol / 0.5 h / 20 - 50 °C / Inert atmosphere

2: zinc; hydrogenchloride / water; methanol / 0.67 h / 20 °C / Reflux

3: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

4: zinc; ammonium chloride / ethanol / 0.33 h / 20 °C

5: pyridine / dichloromethane / 2 h / 0 °C / Inert atmosphere

6: camphor-10-sulfonic acid / methanol / 0.67 h / 20 - 50 °C

7: diamide; tributylphosphine / toluene / 1.17 h / 20 °C / Inert atmosphere; Reflux

8: mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.33 h / 20 °C / Inert atmosphere

9: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / 20 °C / Inert atmosphere

10: caesium carbonate / tetrahydrofuran; acetonitrile / 1 h / 20 - 50 °C

11: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

12: tributylphosphine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

13: trifluorormethanesulfonic acid / dichloromethane / 0.33 h / -78 - 0 °C / Inert atmosphere

14: dmap; triethylamine / tetrahydrofuran; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

15: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.42 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; tributylphosphine; trifluorormethanesulfonic acid; diamide; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; ammonium chloride; caesium carbonate; mercaptoacetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/anie.201204726