(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Base Information

Chemical Name:(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid
CAS No.:823235-90-1
Molecular Formula:C₃₉H₆₇NO₇Si₃
Molecular Weight:746.22
Hs Code.:

Synonyms:(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Suppliers and Price of (6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

There total 7 articles about (6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 823235-80-9
(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid methyl ester

: 823235-90-1
(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 6h;
DOI:10.1021/ol048068x

Reference yield:

: 823235-74-1
(5S,6S)-6-benzyloxycarbonylamino-7-(tert-butyl-dimethyl-silanyloxy)-5-hydroxy-3-oxo-heptanoic acid methyl ester

: 823235-90-1
(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Me₄N(OAc)3BH; AcOH / acetonitrile / -35 - 0 °C

2: 75 percent / 2,6-lutidine / CH₂Cl₂ / 1.25 h / -20 °C

3: H₂ / Pd/C / methanol / 4 h / 20 °C

4: 45 mg / EDC*HCl; HOBt; NMM / CH₂Cl₂ / 20 h / 20 °C

5: NaOH / methanol; tetrahydrofuran / 6 h / 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetramethylammonium triacetoxyborohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/ol048068x

Reference yield:

: 359455-05-3
[(1S,2S)-1-(tert-butyl-dimethyl-silanyloxymethyl)-3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-2-hydroxy-propyl]-carbamic acid benzyl ester

: 823235-90-1
(6S)-6-(2-benzyloxy-benzoylamino)-(3R,5S)-3,5,7-tris-(tert-butyl-dimethyl-silanyloxy)-heptanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / toluene / 4 h / Heating

2: Me₄N(OAc)3BH; AcOH / acetonitrile / -35 - 0 °C

3: 75 percent / 2,6-lutidine / CH₂Cl₂ / 1.25 h / -20 °C

4: H₂ / Pd/C / methanol / 4 h / 20 °C

5: 45 mg / EDC*HCl; HOBt; NMM / CH₂Cl₂ / 20 h / 20 °C

6: NaOH / methanol; tetrahydrofuran / 6 h / 20 °C

With 4-methyl-morpholine; 2,6-dimethylpyridine; sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetramethylammonium triacetoxyborohydride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol048068x