Technology Process of 4-[(Thiophen-2-yl)methyl]glutamic acid
There total 3 articles about 4-[(Thiophen-2-yl)methyl]glutamic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R,4R)-5-Oxo-4-thiophen-2-ylmethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester;
With
lithium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
ethyl acetate;
at 20 ℃;
for 1h;
With
methyloxirane;
In
methanol;
at 20 ℃;
DOI:10.1021/jm020901d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C
1.2: tetrahydrofuran / 2 h / -78 °C
2.1: 2.5 N aq. LiOH / tetrahydrofuran / 2 h / 20 °C
2.2: HCl (g) / ethyl acetate / 1 h / 20 °C
2.3: 38 percent / propylene oxide / methanol / 20 °C
With
lithium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran;
DOI:10.1021/jm020901d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 60 percent / N-bromosuccinimide / AIBN / CCl4 / 4 h / Heating
2.1: lithium hexamethyldisilazide / tetrahydrofuran / 1 h / -78 °C
2.2: tetrahydrofuran / 2 h / -78 °C
3.1: 2.5 N aq. LiOH / tetrahydrofuran / 2 h / 20 °C
3.2: HCl (g) / ethyl acetate / 1 h / 20 °C
3.3: 38 percent / propylene oxide / methanol / 20 °C
With
lithium hydroxide; N-Bromosuccinimide; lithium hexamethyldisilazane;
2,2'-azobis(isobutyronitrile);
In
tetrahydrofuran; tetrachloromethane;
DOI:10.1021/jm020901d
