N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine
CAS No.:1097200-75-3
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

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Chemical Property of N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

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Technology Process of N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

There total 3 articles about N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 104-92-7
1-bromo-4-methoxy-benzene

: C₁₀H₁₆BrNO₂

: 1097200-75-3
N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

Guidance literature:: With manganese; 1,2-bis(diphenylphosphino)propane; cobalt(II) bromide; In acetonitrile; at 40 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.jorganchem.2015.01.001

Reference yield:

: 905293-01-8
[5-(4-methoxy-phenyl)-pent-4-ynyl]-carbamic acid tert-butyl ester

: 1097200-75-3
N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

: C₁₇H₂₃NO₃

Guidance literature:: With Zeise's dimer; tris(pentafluorophenyl)phosphine; In toluene; at 23 ℃; for 3h; Overall yield = 66 percent; Overall yield = 33.1 mg; regioselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1021/acs.orglett.9b03557

Reference yield:

: 151978-50-6
N-(tert-butoxycarbonyl)-pent-4-ynyl-1-amine

: 1097200-75-3
N-(tert-butyloxycarbonyl)-2-(4'-methoxyphenyl)-4,5,6-trihydro-piperidine

: C₁₇H₂₃NO₃

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 16 h / 23 °C / Inert atmosphere

2: Zeise's dimer; tris(pentafluorophenyl)phosphine / toluene / 3 h / 23 °C / Inert atmosphere; Molecular sieve

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Zeise's dimer; triethylamine; tris(pentafluorophenyl)phosphine; In toluene;
DOI:10.1021/acs.orglett.9b03557