dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

Base Information

• Chemical Name: dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate
• CAS No.: 1227268-19-0
• Molecular Formula: C₄₆H₄₀FNO₈
• Molecular Weight: 753.824

Synonyms:dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

Chemical Property of dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

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Technology Process of dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate

There total 1 articles about dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dibenzyl [3-(4-{(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-[4-(acetyloxy)phenyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate (1227268-18-9) → dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate (1227268-19-0)

Guidance literature:

With water; triethylamine; In methanol; at 20 ℃; for 8h; Inert atmosphere;

Reference yield:

dibenzyl (3-{4-[(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}prop-2-yn-1-yl)malonate (1227268-19-0) → (3-{4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid (1227267-80-2)

Guidance literature:

With potassium trimethylsilonate; In ethanol; at 20 ℃; for 6.5h;

upstream raw materials:

dibenzyl [3-(4-{(2S,3R)-3-[(3S)-3-(acetyloxy)-3-(4-fluorophenyl)propyl]-1-[4-(acetyloxy)phenyl]-4-oxoazetidin-2-yl}phenyl)prop-2-yn-1-yl]malonate

Downstream raw materials:

(3-{4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-hydroxyphenyl)-4-oxoazetidin-2-yl]phenyl}propyl)malonic acid

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