phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Base Information

Chemical Name:phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate
CAS No.:1609582-63-9
Molecular Formula:C₁₆H₁₇F₂NO₄
Molecular Weight:325.312
Hs Code.:

Synonyms:phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

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Chemical Property of phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

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Technology Process of phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

There total 2 articles about phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 164732-66-5
3,4-dihydro-2H-pyridine-1-carboxylic acid phenyl ester

: 1609582-63-9
phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With copper(I) oxide; 1,10-Phenanthroline; potassium carbonate; In acetonitrile; at 80 ℃; for 6h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/c4cc01994f

Reference yield: 63.0%

: 667-27-6
Ethyl bromodifluoroacetate

: C₁₂H₁₁NO₃

: 1609582-63-9
phenyl 5-(2-ethoxy-1,1-difluoro-2-oxoethyl)-3,4-dihydro-2H-pyridine-1-carboxylate

Guidance literature:: With 1,10-Phenanthroline; potassium carbonate; iron(II) chloride; In acetonitrile; at 100 ℃; for 16h; regioselective reaction; Inert atmosphere; Sealed tube;
DOI:10.1039/d1nj03673d