4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Chemical Name:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate
CAS No.:1169762-21-3
Molecular Formula:C₃₀H₄₂BrFN₄O₆
Molecular Weight:653.589
Hs Code.:

Synonyms:4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Chemical Property of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

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Technology Process of 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

There total 5 articles about 4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1169762-20-2
C₃₀H₄₂BrFN₄O₆

: 1169762-21-3
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: With lithium amide; tert-butyl alcohol; In toluene; acetonitrile; at 30 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2011.02.071

Reference yield:

: 913543-99-4
tert-butyl 2-cyano-3,3-bis(methylthio)acrylate

: 1169762-21-3
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 1 h / 50 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

4: lithium amide; tert-butyl alcohol / toluene; acetonitrile / 2 h / 30 °C / Inert atmosphere

With lithium amide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.tet.2011.02.071

Reference yield:

: 1169762-17-7
tert-butyl 3-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-2-cyano-3-(methylthio)acrylate

: 1169762-21-3
4-tert-butyl 2-ethyl 3-amino-1-(2-bromo-5-fluorobenzyl)-5-{(3R)-3-[(tert-butoxycarbonyl)amino]-3-methylpiperidin-1-yl}-1H-pyrrole-2,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 10 h / 80 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C / Inert atmosphere

3: lithium amide; tert-butyl alcohol / toluene; acetonitrile / 2 h / 30 °C / Inert atmosphere

With lithium amide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butyl alcohol; In N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.tet.2011.02.071