N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

Base Information

Chemical Name:N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide
CAS No.:1407519-16-7
Molecular Formula:C₂₂H₂₁ClN₅O₃P
Molecular Weight:469.867
Hs Code.:

Synonyms:N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

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Chemical Property of N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

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Technology Process of N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

There total 6 articles about N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1407520-03-9
C₁₉H₂₁ClN₅O₂P

: 471-25-0
Propiolic acid

: 1407519-16-7
N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

Guidance literature:: With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1197953-47-1
(2-aminophenyl)dimethyl phosphorus oxide

: 1407519-16-7
N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

2: ammonia / methanol / 72 h / 100 °C / Sealed tube

3: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 120 °C / Sealed tube

4: ammonium chloride; iron / water; tetrahydrofuran / 65 °C

5: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

With potassium phosphate; ammonia; iron; potassium carbonate; ammonium chloride; dicyclohexyl-carbodiimide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 615-43-0
2-iodophenylamine

: 1407519-16-7
N-(3-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-4-methoxyphenyl)propiolamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C

2: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C

3: ammonia / methanol / 72 h / 100 °C / Sealed tube

4: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 120 °C / Sealed tube

5: ammonium chloride; iron / water; tetrahydrofuran / 65 °C

6: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 20 °C

With potassium phosphate; ammonia; iron; potassium carbonate; ammonium chloride; dicyclohexyl-carbodiimide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;