Technology Process of 3-[1-(2-hydroxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid
There total 7 articles about 3-[1-(2-hydroxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
ethyl 3-[1-(2-hydroxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate;
With
sodium hydroxide;
In
tetrahydrofuran; ethanol; water;
Heating;
With
hydrogenchloride;
In
tetrahydrofuran; ethanol; water;
pH=1;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: titanium tetrachloride / dichloromethane / 3 h / 20 °C
2.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C
3.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C
4.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C
5.1: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube
6.1: palladium on activated charcoal; hydrogen / ethyl acetate; ethanol / 20 °C
7.1: sodium hydroxide / water; tetrahydrofuran; ethanol / Heating
7.2: pH 1
With
potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; titanium tetrachloride; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene;
3.1: |Heck Reaction;
DOI:10.1021/jm500494y
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 20 °C
2.1: palladium diacetate; tris-(o-tolyl)phosphine; triethylamine / toluene / 110 °C
3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C
4.1: johnphos; potassium phosphate; palladium diacetate / 1,2-dimethoxyethane / 110 °C / Sealed tube
5.1: palladium on activated charcoal; hydrogen / ethyl acetate; ethanol / 20 °C
6.1: sodium hydroxide / water; tetrahydrofuran; ethanol / Heating
6.2: pH 1
With
potassium phosphate; lithium aluminium tetrahydride; palladium on activated charcoal; hydrogen; palladium diacetate; triethylamine; tris-(o-tolyl)phosphine; sodium hydroxide; johnphos;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; ethanol; water; ethyl acetate; toluene;
2.1: |Heck Reaction;
DOI:10.1021/jm500494y
![ethyl 3-[1-(2-hydroxyphenyl)-3-(2-phenylethyl)-1H-indol-5-yl]propanoate](/Databaselist/images/loading.webp)
